:Genetics

Using a mixture multidisciplinary of geometry, the biological research and the developed techniques to decide problems in supercomputers, the scientists in the university of California, San Diego had shown for the first time as one genome is organized in the three-dimensional space.

The investigators had lead for Cornelis Murre, a professor of biology in San UC Diego, and Steve Cutchin, senior scientist for services of visualization in the center of supercomputer of San Diego (SDSC), used the gene that codifies locus chain heavy of immunoglobulin responsible to generate diverse types of antibodies to demonstrate the structure of genome.

The comments, the investigators say, allow an introspection in the structure of genome human, that so far elusive remained.

Its results, “the structure 3-D of locus chain weighed of immunoglobulin: The implications for interactions Long-Range Genomic, “are published in the introduction April of 18 of the stackof the periodical.

Because genome is the part most essential of the stack to store and to reach the information genetic, the complete sequence of the DNA of a wide variety of genomes was disclosed in the studies executed in a great number laboratories “a tremendous success that supplied the introspection in the mechanisms that underpin the development of a wide variety of the illnesses,” the authors said.

, Murre however said, “remained to unclear regarding as genome is organized in the three-dimensional space. This is an important edition since that the regulation of the expression of the gene is controlled for interactions of the elements genomic that they are separate for great distances genomic. Thus, our team wanted to determine as genome is structuralized inside of the nucleus.”

The described experiences in the paper of the stack supply, said it, first glimpse in this question. “as a system model, us we use encoding of the gene for locus chain weighed of immunoglobulin, because it is responsible to generate the wide diversity of antibodies.”

In the measurement geometry the distances that separate the some parts of the gene, Murre said, the investigators, in the contribution with the Cutchin in the SDSC, to follow used to decide the first structure of one locus genetic.

His works, said Cutchin, involved computational geometry, visualization scientific, computational methods and numerical methods.

“the resultant structure sample that the gene of antibody is organized in ‘ flower-as ‘ the structures that are connected by linkers,” said Murre. “these flowers contain the some parts that finally generate the wide variety of antibodies. That is the first time that used geometry estve to determine the one structure locus genetic. Finally, the same approach must be used elucidate the structure of genome human whole number.”

They were contributing ingualmente to the work Suchit Jhunjhunwala, Mandy M. Pico, and Menno C. Zelm pickup.truck, everything with the division of biological sciences in San UC Diego; RibletRoy of the institute of the pines of molecular Torrey for studies; Jacques J.M. pickup.truck Dongen and G. frank GrosveldErasmus MC in Rotterdam, the Netherlands; e Tobias the Knoch of the university of Heidelberg, Germany.

To finance for the research was supplied by the national justinian codes of the health.

University of California, San Diego
Communications Of The University, Dr. Of 0938 9500 Gilman.
LaJolla, Ca 92093
United States
http://infopath.ucsd.edu