:Genetics

The investigators had traced for are of a region in chromosome human 1 that it contributes to the levels genetically elevated of triglyceride of the blood, a factor of main risk for the heart illness.

Triglycerides (TG), the main form of the dietary fat, circulates continuously in the blood, but if its concentration elevates the risk of the illness of the atherosclerosis and subsequently of heart increases. The levels circulating of the TG depend on many factors including the diet, the exercise, and to smoke, but around 40% of the variation in the population must to genetics.

To find the genes that contribute to the increased levels of the TG, Qing Wang and the colleagues they had made the sweepings of 714 caucasians of 388 families with premature illness of heart. They had identified a region of the novel in chromosome 1, 1p31-32.

When this locus genetic to contain 375 known genes, the investigators had detached three genes that are special promising candidates: angiopoietin-as 3, that it inhibits enzymes that they break below fats; the receiver for leptin of hormone of the appetite; e protein 2 of the carrier of sterol, that it helps cholesterol of I talk it in acid of bile.

The investigators also write down that one another recent study identified only polymorphism of nucleotide associated with the levels elevated of the TG in the accurate same a region, solidifying this part of chromosome 1 as the region of the TG.

The article was adaptou today for Medical Notice of the release of the original press.

Corresponding Author: Qing Kenneth Wang, center for genetics and the cardiovascular department of cardiology molecular, foundation of the clinic of Cleveland, Cleveland, OH

Source: Zagorski Notch
American society for biochemistry and molecular biology